Codexis, Inc. | Layoff Event

Layoff Details

Reason

Codexis, Inc. implemented a workforce reduction of approximately 24% (46 positions) coinciding with a change in company leadership, with Dr. Alison Moore succeeding Dr. Stephen Dilly as CEO, effective November 7, 2025. This strategic overhaul, announced on November 6, 2025, aims to streamline operations, reduce operational expenses by recognizing an approximate $3.5 million expense in the fourth quarter of 2025, and extend the company's cash runway through 2027. The company is pivoting its strategic focus away from small molecule biocatalysis due to pricing pressures and towards innovative manufacturing solutions in its ECO Synthesis platform for oligonucleotide production. This includes reducing sales and marketing efforts in the small molecule biocatalysis segment. The workforce reduction is expected to be substantially completed by January 2026.

Affected Locations

Redwood CityCA

Affected Departments

Small Molecule Biocatalysis (especially sales and marketing)Other departments not aligned with ECO Synthesis platform

Stock Performance Around Layoff

Sources (5)