Tango Therapeutics, Inc.

Tango Therapeutics, Inc.

Biotechnology Healthcare Boston, MA, United States TNGX (NGM)
Quarter: Q1 2026 Reported: January 8, 2026 Sentiment: Neutral

Tango Therapeutics, Inc., a precision oncology company, focuses on the discovery and development of drugs in defined patient populations with unmet medical need. The company develops methylthioadenosine -cooperative protein arginine methyltransferase 5 (PRMT5) inhibitors, including TNG462, which is in Phase 1/2 clinical trial for treating pancreatic and lung cancer; and TNG456, a brain-penetrant PRMT5 inhibitor for the treatment of glioblastoma. It is developing TNG260, a co-repressor of repressor element-1 silencing transcription inhibitor to reverse the immune evasion effect of serine-threonine kinase 11 loss-of-function mutations for treating lung cancer. The company was founded in 2017 and is headquartered in Boston, Massachusetts.

Analysis Summary

Tango Therapeutics, Inc. (TNGX) reported significant executive leadership changes effective January 8, 2026, as detailed in its Q1 2026 filing. Dr. Barbara Weber, the former President and Chief Executive Officer, retired from her executive role but will continue to serve the company as Executive Chair until December 31, 2026, providing advisory services for a smooth transition. Her departure was explicitly stated not to be a result of any disagreement with the company's operations, policies, or practices, indicating a planned succession. Dr. Weber's compensation as Executive Chair includes an annual base salary of $362,000 and a prorated target cash bonus of 60% of her prior base salary.

Succeeding Dr. Weber, Dr. Malte Peters, a current member of the Board of Directors, was appointed as the new President and Chief Executive Officer. Dr. Peters' compensation package is robust, featuring an annual base salary of $720,000 and a target cash bonus opportunity of 60% of his base salary, prorated for partial service. Furthermore, to align his long-term interests with shareholder value, Dr. Peters was granted an option to purchase 1,650,000 shares of common stock, vesting over approximately four years, and 350,000 restricted stock units (RSUs) vesting in three equal annual installments. His full employment agreement is contingent upon receiving U.S. work authorization.

It is important to note that this specific filing, an Item 2.02 and 5.02 disclosure, primarily focuses on these leadership changes and their associated compensatory arrangements. The document explicitly states that it 'does not present all information necessary for an understanding of the Company’s financial condition as of December 31, 2025' and therefore, no Q1 2026 financial performance data, such as revenue, earnings, EPS, or forward guidance, is available within this transcript. Consequently, a detailed financial performance breakdown, analysis of strategic initiatives beyond leadership, competitive positioning, or market trends cannot be derived from this document. The company did issue a press release and updated its corporate presentation on January 8, 2026, to announce these changes to investors and analysts.

Key Highlights

  • Dr. Barbara Weber resigned as President and CEO, effective January 8, 2026.
  • Dr. Weber transitioned to Executive Chair, providing advisory services until December 31, 2026.
  • Dr. Malte Peters, a board member, was appointed as the new President and CEO.
  • The leadership change was described as smooth and not due to disagreements.
  • Dr. Peters received a significant equity grant: 1,650,000 stock options and 350,000 RSUs.
  • New CEO's annual base salary set at $720,000 with a 60% target cash bonus.
  • No Q1 2026 financial performance data was provided in this specific transcript.

Financial Metrics

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revenue
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guidance
net income
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Stock Performance (90 Days)

Data through Feb 13, 2026
Layoff Events
Earnings Calls

Positive Signals

  • Smooth and planned leadership transition, not due to disagreements.
  • Former CEO remains involved as Executive Chair, ensuring continuity.
  • New CEO is an existing board member, suggesting familiarity and alignment.
  • Substantial equity grant for new CEO aligns his interests with long-term shareholder value.
  • Company proactively communicated changes via press release and updated presentation.

Risks & Concerns

  • Lack of Q1 2026 financial performance data in this specific filing, limiting comprehensive analysis.
  • Potential for operational disruption during any leadership transition, despite stated smoothness.
  • Reliance on the new CEO's ability to effectively lead and execute company strategy.
  • New CEO's full employment agreement is contingent on obtaining U.S. work authorization.
  • Increased executive compensation costs with the new CEO's package.

Full Transcript

Recent Tango Therapeutics, Inc. News

Stock Price

$12.90
TNGX· NGM
1.82% day

Company Info

Industry
Biotechnology
Sector
Healthcare
Headquarters
Boston, MA, United States
CEO
Dr. Barbara L. Weber M.D.
Employees
155
View Company Profile

Layoff Stats

Layoff Events
0
Total Affected
0

Recent Layoffs

No canonical layoff events recorded for this company.

Financials

Market Cap $1.17B
Revenue $66.5M
Profit Margin -151.1%
Cash $152.8M
Debt $34.8M